I think your Top 5 supplements would vary based on your goal. For example, top supplements for maximizing muscle would vary from supplements focused on longevity. As I’ve aged, my list has changed to focus more on longevity. Some have remained on the list, like fish oil, curcumin…while I’ve added others such as CoQ10, others for blood pressure, liver, and kidney support. I’d outline your specific goals first, then determine your appropriate list. Also, track your health, so you know what works/doesn’t work. I do blood pressure every month, cholesterol every 1 to 2 years, and as Joe mentions above, blood work as well.